Efnb2^tm1.1Bush
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm1.1Bush
• Name: ephrin B2; targeted mutation 1.1, Jeffrey Bush
• MGI ID: MGI:5882571
• Synonyms: Efnb2^CR
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm1.1Bush page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226395
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into exon 1 a loxP site, splice acceptor, H2B-Cherry reporter gene, triple stop polyadenylation sequence, loxP site and FRT site. Flpo-recombination removed the FRT-flanked neomycin resistance cassette to leave the single FRT site. (J:226395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 27 strains or lines available

References

• Original: J:226395 Lewis AE, et al., Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature. Dev Biol. 2015 Oct 15;406(2):186-95
• All: 2 reference(s)