Gt(ROSA)26Sor^{tm4.1(SORL1*)Tew}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm4.1(SORL1*)Tew}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4.1, Thomas E Willnow
• MGI ID: MGI:5882426
• Synonyms: Rosa26^TgSORLftaf
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm4.1(SORL1*)Tew} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226400
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into the locus the human cDNA lacking the retromer binding sites preceded by a splice acceptor and floxed neomycin resistance cassette and followed by a polyadenylation sequence. Cre-mediated recombination removed the resistance cassette and allowed for expression of the human cDNA. (J:226400)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:226400 Dumanis SB, et al., Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain. J Neurosci. 2015 Sep 16;35(37):12703-13
• All: 1 reference(s)