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Tg(Cdh5-cre,-GFP)21Msri
Transgene Detail
Summary
Symbol: Tg(Cdh5-cre,-GFP)21Msri
Name: transgene insertion 21, Michele Souyri
MGI ID: MGI:5882215
Synonyms: Tg(Cdh5-cre,-GFP)21, VEC
Transgene: Tg(Cdh5-cre,-GFP)21Msri  Location: unknown  
Alliance: Tg(Cdh5-cre,-GFP)21Msri page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase, Reporter)
Mutation:    Insertion
 
Tg(Cdh5-cre,-GFP)21Msri expression driven by 1 gene
 
Mutation detailsMice with this transgene express Cre recombinase under the control of the regulatory sequences of mouse cadherin 5 (also called vascular endothelial cadherin) residing between ~2500 base pairs upstream of the translation initiation codon and the middle of the first intron, wherein resides an enhancer sequence. The Cre coding sequence is followed by an internal ribosomal entry site and sequence encoding green fluorescent protein (GFP). At embryonic day (E) 10.5, embryos bearing both this transgene and a lacZ- expressing Cre reporter exhibit beta-galactosidase activity/immunoreactivity in the intersomitic vessels, endocardium, aorta, fetal liver, yolk sac, and umbilical and vitelline arteries. In the E11.5-E12.5 placenta, activity is observed in the umbilical artery and primarily in the large vessels, rather than the labyrinth, of the chorionic plate. (J:198989)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdh5 (mouse)
Summary of all recombinase alleles driven by Cdh5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:198989 Oberlin E, et al., Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression. Int J Dev Biol. 2010;54(6-7):1165-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory