Gsdmd^igl1351
Chemically induced Allele Detail

Summary

• Symbol: Gsdmd^igl1351
• Name: gasdermin D; igl1351
• MGI ID: MGI:5882072
• Synonyms: Gsdmd^I105N
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^igl1351 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a point mutation that results in the amino acid substitution of asparagine for isoleucine at position 105 (I105N). (J:226780)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 35 strains or lines available

References

• Original: J:226780 Kayagaki N, et al., Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015 Oct 29;526(7575):666-71
• All: 8 reference(s)