Adgrb2^m1Djs
Chemically induced Allele Detail

Summary

• Symbol: Adgrb2^m1Djs
• Name: adhesion G protein-coupled receptor B2; mutation 1, David J Speca
• MGI ID: MGI:5829557
• Synonyms: Adgrb2^R619W
• Gene: Adgrb2 Location: Chr4:129878663-129916426 bp, + strand Genetic Position: Chr4, 63.43 cM
• Alliance: Adgrb2^m1Djs page

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a C-to-T transition at chr4:129686542 (NCBI Build 37, mm9) which changes an arginine residue to a tryptophan at residue 619 (R619W) in the GAIN domain-encoding region of the encoded protein. (J:250129)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrb2 Mutation: 71 strains or lines available

References

• Original: J:250129 Speca DJ, et al., Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Mamm Genome. 2017 Dec;28(11-12):465-475
• All: 1 reference(s)