Cstbtm2Yah
Targeted Allele Detail
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Symbol: |
Cstbtm2Yah |
Name: |
cystatin B; targeted mutation 2, Yann Herault |
MGI ID: |
MGI:5828767 |
Synonyms: |
CSTB5RT, Cstbtm1Yah |
Gene: |
Cstb Location: Chr10:78261504-78263456 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Cstbtm2Yah page
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutation: |
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Duplication
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Mutation details: A tandem duplication of the gene resulted from integration of a vector containing a neomycin selection cassette, a loxP site, the 5' end of the Hprt gene, and a homology region including all three exons of the targeted gene. The two copies of the gene are separated in the mouse chromosome by the vector sequence. Quantitative real-time PCR of total RNA extracts of liver and brain demonstrated ~2-fold greater transcript levels, relative to those of wild-type mice, in both tissues of mice with three gene copies and ~3-fold increase in mice with four copies.
(J:181132)
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Original: |
J:181132 Brault V, et al., Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. PLoS One. 2011;6(11):e27845 |
All: |
2 reference(s) |
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