Coro1a^tm1.1Pngr
Targeted Allele Detail

Summary

• Symbol: Coro1a^tm1.1Pngr
• Name: coronin, actin binding protein 1A; targeted mutation 1.1, Josef M Penninger
• MGI ID: MGI:5825182
• Gene: Coro1a Location: Chr7:126298946-126303925 bp, - strand Genetic Position: Chr7, 69.25 cM, cytoband F3
• Alliance: Coro1a^tm1.1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237967
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre/loxp-mediated deletion removed the coding sequence after exon 1. Western blot analysis confirmed the absence of protein expression in the spleen and lymph nodes. (J:237967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coro1a Mutation: 25 strains or lines available

References

• Original: J:237967 Kaminski S, et al., Coronin 1A is an essential regulator of the TGFbeta receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. J Autoimmun. 2011 Nov;37(3):198-208
• All: 2 reference(s)