Mapkapk3^tm1Mgl
Targeted Allele Detail

Summary

• Symbol: Mapkapk3^tm1Mgl
• Name: mitogen-activated protein kinase-activated protein kinase 3; targeted mutation 1, Matthias Gaestel
• MGI ID: MGI:5825024
• Gene: Mapkapk3 Location: Chr9:107132126-107167076 bp, - strand Genetic Position: Chr9, 57.98 cM
• Alliance: Mapkapk3^tm1Mgl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126340
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exon 3, which encodes subdomains III and IV. (J:126340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapkapk3 Mutation: 24 strains or lines available

References

• Original: J:126340 Zaru R, et al., The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol. 2007 Nov;8(11):1227-35
• All: 6 reference(s)