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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1.1(CAG-AOX)Htj
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Howard T Jacobs
MGI ID: MGI:5824337
Synonyms: AOXRosa26, Gt(ROSA)26Sortm1.1Htj
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1.1(CAG-AOX)Htj page
Germline Transmission:  Earliest citation of germline transmission: J:238705
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA construct comprising a CAG promotor, the ascidian Ciona intestinalis AOX (alternative oxidase) gene, a beta globin intron and a polyA site, plus an FLP site flanked neomycin resistance gene cassette were inserted into the locus. The neo cassette was removed through flp-mediated recombination. This creates an allele ubiquitously expressing an oxidase gene of a type not found in mammals. (J:238705)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  958 strains or lines available
Original:  J:238705 Szibor M, et al., Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology. Dis Model Mech. 2017 Feb 01;10(2):163-171
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
The Jackson Laboratory