Tg(Alb1-IKBKB*S177E*S181E)1Mka
Transgene Detail

Summary

• Symbol: Tg(Alb1-IKBKB*S177E*S181E)1Mka
• Name: transgene insertion 1, Michael Karin
• MGI ID: MGI:5824105
• Synonyms: LIKKbeta^tg
• Transgene: Tg(Alb1-IKBKB*S177E*S181E)1Mka Location: unknown
• Alliance: Tg(Alb1-IKBKB*S177E*S181E)1Mka page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Alb1-IKBKB*S177E*S181E)1Mka expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IKBKB (3551)

  Ikbkb

  (MGI:1338071)

• Mutation details: A transgenic construct in which the expression of constitutively active human IKBKB gene with the introduced S177E and S181E mutations was driven under the albumin promoter. (J:238078)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:238078 Liu J, et al., Inflammation Improves Glucose Homeostasis through IKKbeta-XBP1s Interaction. Cell. 2016 Nov 03;167(4):1052-1066.e18
• All: 1 reference(s)