Brca1^tm2Jjon
Targeted Allele Detail

Summary

• Symbol: Brca1^tm2Jjon
• Name: breast cancer 1, early onset; targeted mutation 1, Jos Jonkers
• MGI ID: MGI:5823771
• Synonyms: Brca1^185stop
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm2Jjon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237116
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: Nonchemically modified deoxyribonucleotides were used to introduce the (5-ATGCAGAAAATCTTAGAGTAGGCGATCTGGTAAGTCAACA-3) mutation into a mouse ES cell line. This alteration is a substitution of 3 nucleotides (TCC to AAG) at position 185, resulting in an early STOP codon at aa 24 of the encoded protein. (J:237116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:237116 Drost R, et al., BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest. 2016 Aug 01;126(8):2903-18
• All: 1 reference(s)