Gt(ROSA)26Sor^{tm1(CAG-Ngf,-EGFP)Tcw}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Ngf,-EGFP)Tcw}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Timothy C Wang
• MGI ID: MGI:5823558
• Synonyms: Gt(ROSA)26Sor^{tm1(CAG-Ngf,-GFP)Tcw}, R26-LSL-Ngf-IRES-GFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Ngf,-EGFP)Tcw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238420
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Ngf,-EGFP)Tcw} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ngf (MGI:97321)

• Mutation details: The following elements were inserted into intron 1 of the gene: CAG promoter, loxP-STOP-loxP, mouse cDNA, IRES, EGFP and polyA site to create a conditional ready allele. (J:238420)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1058 strains or lines available

References

• Original: J:238420 Hayakawa Y, et al., Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer Cell. 2017 Jan 09;31(1):21-34
• All: 4 reference(s)