Pla2g7^tm1.1Ahac
Targeted Allele Detail

Summary

• Symbol: Pla2g7^tm1.1Ahac
• Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); targeted mutation 1.1, Angela Haczku
• MGI ID: MGI:5823197
• Gene: Pla2g7 Location: Chr17:43879009-43923093 bp, + strand Genetic Position: Chr17, 19.74 cM, cytoband C
• Alliance: Pla2g7^tm1.1Ahac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238620
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeted allele was generated by inserting two loxP sites flanking a neo cassette within intron 3 and an additional loxP site within intron 2 via homologous recombination. Resulting mice were crossed to a germline Cre-deleter strain to remove exon 3 and neo selection cassette leaving behind a single loxP and a single FRT sites. (J:238620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g7 Mutation: 17 strains or lines available

References

• Original: J:238620 Jiang Z, et al., The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. Respir Res. 2012 Nov 12;13:100
• All: 3 reference(s)