Sox13^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Sox13^{tm1d(EUCOMM)Wtsi}
• Name: SRY (sex determining region Y)-box 13; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5818676
• Gene: Sox13 Location: Chr1:133310041-133352115 bp, - strand Genetic Position: Chr1, 57.91 cM
• Alliance: Sox13^{tm1d(EUCOMM)Wtsi} page
• IMPC: Sox13 gene page

Mutation origin

• Mutant Cell Line: EPD0226_6_B08
• Germline Transmission: Earliest citation of germline transmission: J:231103
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 133318064 of Chromosome 1 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 133319053. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression resulted in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:231103)

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox13 Mutation: 58 strains or lines available

References

• Original: J:231103 Baroti T, et al., Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. J Neurochem. 2016 Jan;136(2):316-28
• All: 2 reference(s)