Tg(TcraG9C8)22Fsw
Transgene Detail

Summary

• Symbol: Tg(TcraG9C8)22Fsw
• Name: transgene insertion 22, F Susan Wong
• MGI ID: MGI:5818040
• Synonyms: A22
• Transgene: Tg(TcraG9C8)22Fsw Location: unknown
• Alliance: Tg(TcraG9C8)22Fsw page

Transgene origin

• Strain of Origin: NOD/Caj

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Transgenic mice were generated by isolating mouse TCR genomic DNA from G9C8 cloned T-cells, which have previously been shown to have specific reactivity to amino acids 1523 of the insulin beta-chain. Tcralpha (Valpha18S1 Jalpha18 Calpha) chain genomic clone was injected into ova to establish three transgenic mouse lines, 17, 22 and 14. Line 22 was used for subsequent studies. (J:151124)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:151124 Wong FS, et al., Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes. Diabetes. 2009 May;58(5):1156-64
• All: 11 reference(s)