Col5a2^tm1.2Dgr
Targeted Allele Detail

Summary

• Symbol: Col5a2^tm1.2Dgr
• Name: collagen, type V, alpha 2; targeted mutation 1.2, David S Greenspan
• MGI ID: MGI:5817900
• Gene: Col5a2 Location: Chr1:45413491-45542442 bp, - strand Genetic Position: Chr1, 23.69 cM, cytoband C1
• Alliance: Col5a2^tm1.2Dgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223298
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The loxP flanked exon 1 was removed via cre-mediated recombination. (J:223298)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col5a2 Mutation: 65 strains or lines available

References

• Original: J:223298 Park AC, et al., Homozygosity and Heterozygosity for Null Col5a2 Alleles Produce Embryonic Lethality and a Novel Classic Ehlers-Danlos Syndrome-Related Phenotype. Am J Pathol. 2015 Jul;185(7):2000-11
• All: 1 reference(s)