Dkk1^tm3.1Sia
Targeted Allele Detail

Summary

• Symbol: Dkk1^tm3.1Sia
• Name: dickkopf WNT signaling pathway inhibitor 1; targeted mutation 3.1, Shinichi Aizawa
• MGI ID: MGI:5817775
• Gene: Dkk1 Location: Chr19:30523276-30526896 bp, - strand Genetic Position: Chr19, 25.16 cM, cytoband C2
• Alliance: Dkk1^tm3.1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222398
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vectors were constructed with the PR23-98J4 BAC clone. H2B-mCherry was inserted into the first exon of Dkk1 with a loxP-flanked PGK-Neo cassette. Cre-mediated recombination excised the PGK-Neo cassette, leaving a single loxP site behind. (J:222398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dkk1 Mutation: 19 strains or lines available

References

• Original: J:222398 Hoshino H, et al., AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression. Dev Biol. 2015 Jun 15;402(2):175-91
• All: 1 reference(s)