Esyt1^tm1.3Tmss
Targeted Allele Detail

Summary

• Symbol: Esyt1^tm1.3Tmss
• Name: extended synaptotagmin-like protein 1; targeted mutation 1.3, Tom Moss
• MGI ID: MGI:5817357
• Synonyms: esyt1 delta
• Gene: Esyt1 Location: Chr10:128346117-128361728 bp, - strand Genetic Position: Chr10, 76.85 cM
• Alliance: Esyt1^tm1.3Tmss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236096
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre- and Flp-mediated recombination removed the promoter-driven neomycin selection cassette, the IRES-BetaGal reporter expression cassette and critical exons (exons 3 through 7) of the targeted KO-first, conditional ready, parental allele Esyt1^tm1Tmss resulting in insertion of an FRT and a loxP site into intron 2 of the gene. (J:236096)

Expression

In Mice Carrying this Mutation:

61 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esyt1 Mutation: 50 strains or lines available

References

• Original: J:236096 Tremblay MG, et al., Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility. Cell Cycle. 2016 Sep;15(17):2360-6
• All: 2 reference(s)