Trpm2^tm1.1Dpc
Targeted Allele Detail

Summary

• Symbol: Trpm2^tm1.1Dpc
• Name: transient receptor potential cation channel, subfamily M, member 2; targeted mutation 1.2, David Corey
• MGI ID: MGI:5817179
• Synonyms: Trpm2^fl
• Gene: Trpm2 Location: Chr10:77743556-77805746 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Trpm2^tm1.1Dpc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237834
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-loxP-neomycin-FRT-loxP cassette is inserted upstream of exon 21 (encoding amino acids 929-985, the fifth transmembrane domain and pore). A third loxP is inserted downstream of exon 21. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 21 floxed. (J:237834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpm2 Mutation: 111 strains or lines available

References

• Original: J:237834 Wu X, et al., Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS One. 2016;11(5):e0155577
• All: 2 reference(s)