Il23r^tm1Kuv
Targeted Allele Detail

Summary

• Symbol: Il23r^tm1Kuv
• Name: interleukin 23 receptor; targeted mutation 1, Universitat Kiel
• MGI ID: MGI:5816976
• Synonyms: Il23r^flox, Il23r^tm1.1Geno
• Gene: Il23r Location: Chr6:67399916-67468839 bp, - strand Genetic Position: Chr6, 30.85 cM
• Alliance: Il23r^tm1Kuv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237237
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The proximal loxP site was inserted together with a neomycin selection cassette flanked by FRT sites within intron 3 of the Il23r gene, the distal loxP site was introduced within intron 4. The resultant mouse line was bred to a FLP deleter-line, which ubiquitously expresses Flp-recombinase to excise the neomycin selection cassette. (J:237237)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il23r Mutation: 71 strains or lines available

References

• Original: J:237237 Yoon J, et al., IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 Sep 19;213(10):2147-66
• All: 9 reference(s)