Grem1^tm1.2Ecan
Targeted Allele Detail

Summary

• Symbol: Grem1^tm1.2Ecan
• Name: gremlin 1, DAN family BMP antagonist; targeted mutation 1.2, Ernesto Canalis
• MGI ID: MGI:5816718
• Synonyms: Grem1^-
• Gene: Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
• Alliance: Grem1^tm1.2Ecan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182788
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination has deleted a DNA segment extending from 335 bp upstream of exon 2, which contains the entire coding sequence, to a site 550 bp downstream of the stop codon within the exon, leaving a single loxP site. The remaining 66 bp of exon 2 were deleted in the original targeted allele, Grem1^tm1Ecan (J:126375)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem1 Mutation: 19 strains or lines available

References

• Original: J:126375 Gazzerro E, et al., Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem. 2007 Oct 26;282(43):31549-57
• All: 2 reference(s)