Map1a^tm1Noh
Targeted Allele Detail

Summary

• Symbol: Map1a^tm1Noh
• Name: microtubule-associated protein 1 A; targeted mutation 1, Nobutaka Hirokawa
• MGI ID: MGI:5816623
• Gene: Map1a Location: Chr2:121120081-121141313 bp, + strand Genetic Position: Chr2, 60.37 cM
• Alliance: Map1a^tm1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227842
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked lacZ and neomycin gene selection cassette replaced part of intron 2 and exon 3, including the ATG site. The absence of encoded protein in the mutant mouse brain was confirmed by Western blot analysis using two different specific antibodies. (J:227842)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map1a Mutation: 109 strains or lines available

References

• Original: J:227842 Takei Y, et al., Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J Neurosci. 2015 Nov 25;35(47):15539-54
• All: 1 reference(s)