Dpy30tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Dpy30tm1c(KOMP)Wtsi |
Name: |
dpy-30, histone methyltransferase complex regulatory subunit; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5812161 |
Synonyms: |
Dpy30F |
Gene: |
Dpy30 Location: Chr17:74606469-74630939 bp, - strand Genetic Position: Chr17, 45.64 cM
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Alliance: |
Dpy30tm1c(KOMP)Wtsi page
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IMPC: |
Dpy30 gene page |
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Mutant Cell Line: |
EPD0714_4_A06 |
Germline Transmission: |
Earliest citation of germline transmission:
J:237262
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 74614423 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 74615334. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exons.
(J:237262)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dpy30 Mutation: |
45 strains or lines available
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Original: |
J:237262 Yang Z, et al., Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells. J Exp Med. 2016 Oct 17;213(11):2349-2364 |
All: |
5 reference(s) |
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