Rcor2^tm1.1Gman
Targeted Allele Detail

Summary

• Symbol: Rcor2^tm1.1Gman
• Name: REST corepressor 2; targeted mutation 1.1, Gail Mandel
• MGI ID: MGI:5811641
• Synonyms: Rcor2^fl
• Gene: Rcor2 Location: Chr19:7244759-7252590 bp, + strand Genetic Position: Chr19, 5.32 cM
• Alliance: Rcor2^tm1.1Gman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239534
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP-flanked neomycin resistance (neo) cassette upstream of exon 5 and a third loxP site downstream of exon 9. Cre-mediated recombination removed the floxed neo cassette. (J:239534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rcor2 Mutation: 37 strains or lines available

References

• Original: J:239534 Monaghan CE, et al., REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E406-E415
• All: 1 reference(s)