Gdac1^129S1/SvImJ
QTL Variant Detail

Summary

• QTL variant: Gdac1^129S1/SvImJ
• Name: glutathione peroxidase deficiency associated colitis 1; 129S1/SvImJ>
• MGI ID: MGI:5810687
• QTL: Gdac1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: 129S1/SvImJ

Variant description

• Allele Type: QTL

Notes

GPX1/2 DKO mice on a 129 genetic background had the most aggressive colitis compared with B6;129 and B6 mice. Analysis of the B6 loci in 129 N5, N7 and N10 mice pointed to a region of Chromosome 2 contributing to mild symptoms.

References

• Original: J:171572 Esworthy RS, et al., Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2. Inflamm Bowel Dis. 2011 Jun;17(6):1373-86
• All: 1 reference(s)