Kdm6a^tm1.1Rbo
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm1.1Rbo
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1.1, Remy Bosselut
• MGI ID: MGI:5807356
• Synonyms: Utx^f
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm1.1Rbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227020
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-loxP-neomycin-FRT-loxP cassette introduced upstream of exon 24 and a loxP site downstream of exon 24. Exon 24 encodes the catalytic JmjC domain. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 24 floxed. (J:227020)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 37 strains or lines available

References

• Original: J:227020 Manna S, et al., Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation. Nat Commun. 2015;6:8152
• All: 2 reference(s)