Dgkz^tm2Gak
Targeted Allele Detail

Summary

• Symbol: Dgkz^tm2Gak
• Name: diacylglycerol kinase zeta; targeted mutation 2, Gary A Koretzky
• MGI ID: MGI:5806790
• Gene: Dgkz Location: Chr2:91763169-91806209 bp, - strand Genetic Position: Chr2, 50.63 cM, cytoband E1
• Alliance: Dgkz^tm2Gak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236699
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP-flanked neomycin resistance (neo) cassette upstream of exon 7, and a single loxP site downstream of exon 11. (J:236699)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dgkz Mutation: 64 strains or lines available

References

• Original: J:236699 Schmidt AM, et al., Regulatory T cells require TCR signaling for their suppressive function. J Immunol. 2015 May 1;194(9):4362-70
• All: 2 reference(s)