Tg(Nes-TK*,-EGFP)145Sker
Transgene Detail

Summary

• Symbol: Tg(Nes-TK*,-EGFP)145Sker
• Name: transgene insertion 145, Steven Kernie
• MGI ID: MGI:5806657
• Synonyms: delta-HSV-TK
• Transgene: Tg(Nes-TK*,-EGFP)145Sker Location: unknown
• Alliance: Tg(Nes-TK*,-EGFP)145Sker page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The transgene is designed with ~5 kbp mouse nestin promoter/enhancer sequences, a ~1.1 kbp modified herpes simplex virus thymidine kinase fragment (delta-HSV-TK), a ~1.3 kbp IRES-eGFP cassette, an SV40 polyadenylation sequence and a ~0.8 kbp mouse nestin intron 2 sequence. Thymidine kinase xpression is coincident with early hippocampal progenitors. The investigator reports that eGFP expression is observable by direct fluorescence and can be enhanced it with antibody staining. (J:142499)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:142499 Yu TS, et al., Traumatic brain injury-induced hippocampal neurogenesis requires activation of early nestin-expressing progenitors. J Neurosci. 2008 Nov 26;28(48):12901-12
• All: 11 reference(s)