Tsve1^Peru-Wallace
QTL Variant Detail

Summary

• QTL variant: Tsve1^Peru-Wallace
• Name: variable short tail (Tsv) enhancer 1; Peru-Wallace
• MGI ID: MGI:5806237
• QTL: Tsve1 Location: Chr7:55889508-87142720 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: Peru-Wallace

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:14653

A modifier gene that alters the tail length of Tsv/+ mice was identified and symbolized as Tsve (variable short tail (Tsv) enhancer in an earlier paper, J:14795. In this original paper, the locus for Tsve (now called Tsve1) is suggested as mapping to a short segment of Chromosome 7 between Tyr (c, albino) and Oca2 (p, pink-eyed dilution).

The current paper (J:14653) resolved the Tsve1 locus into two QTL:

Tsve1, the original locus, is located between Oca2 and Tyr, and represents the original locus identified in J:14795. The modifier allele from the Peru-Wallace stock confers longer tail length and greater viability than the allele(s) from laboratory mouse strains. Crosses involving different but unspecified laboratory linkage-testing stocks segregating for Tsv suggested the existence of at least four alleles of Tsve1, including Tsve^Peru-Coppock, which the authors call m0 and which confers a longer-tailed phenotype on a Tsv/+ background, and m1, m2 and m3, the relative tail lengths they conferred to Tsv/+ mice are m0 > m1 > m2 > m3. The alleles of Tsve1 are designated m0, for the longer-tailed variant of Peru-Wallace, and m1, m2, and m3 for the partially lethal, successively shortening laboratory alleles." We have named the wild-derived (m0) allele Tsve1, as it was present in the original Peru-Wallace stock, prior to occurrence of the Tsv mutation.

Tsve2, the novel locus identified in this paper, lies outside the Oca2-Tyr interval (which end is not known), and its alleles (both apparently from lab stocks) are designated n1 and n2. The authors do not identify the lab stocks used, so no alleles were associated with this QTL in MGD.

References

• Original: J:14653 Wallace ME, Modification of the Tsv phenotype by a segment of Chromosome 7. Mouse Genome. 1993;91(2):339-41
• All: 1 reference(s)