Htt^tm2.1Ics
Targeted Allele Detail

Summary

• Symbol: Htt^tm2.1Ics
• Name: huntingtin; targeted mutation 2.1, Mouse Clinical Institute
• MGI ID: MGI:5806066
• Synonyms: Hdh^S421D
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm2.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (AGC to GAC) result in the amino acid substitution of aspartic acid for serine at position 421 (S421D). Cre-mediated recombination removed the selection cassette. (J:225968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 178 strains or lines available

References

• Original: J:225968 Thion MS, et al., Unraveling the Role of Huntingtin in Breast Cancer Metastasis. J Natl Cancer Inst. 2015 Oct;107(10)
• All: 3 reference(s)