Adam11^tm1.1Jno
Targeted Allele Detail

Summary

• Symbol: Adam11^tm1.1Jno
• Name: a disintegrin and metallopeptidase domain 11; targeted mutation 1.1, Jeffrey Noebels
• MGI ID: MGI:5805559
• Synonyms: Adam11^delta12-18
• Gene: Adam11 Location: Chr11:102652265-102671088 bp, + strand Genetic Position: Chr11, 66.48 cM
• Alliance: Adam11^tm1.1Jno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 12. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 18. Cre-mediated recombination removed exons 12 through 18 along with the selection cassette. This allele produces a truncated protein lacking the disintegrin and transmembrane domains. (J:226018)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam11 Mutation: 38 strains or lines available

References

• Original: J:226018 Kole MJ, et al., Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015 Aug 12;35(32):11433-44
• All: 1 reference(s)