Tg(Acta2-AKR1B1)#Pfk
Transgene Detail

Summary

• Symbol: Tg(Acta2-AKR1B1)#Pfk
• Name: transgene insertion, Peter Kador
• MGI ID: MGI:5805235
• Synonyms: SMAA-hAR
• Transgene: Tg(Acta2-AKR1B1)#Pfk Location: unknown
• Alliance: Tg(Acta2-AKR1B1)#Pfk page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Acta2-AKR1B1)#Pfk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AKR1B1 (231)

  Akr1b1

  (MGI:1353494)

• Mutation details: The transgene contains the promoter region of the mouse actin, alpha 2, smooth muscle, aorta (Acta2) gene, including 1074 bp of 5' flanking region, the transcription start site, the 48-bp first exon, the ~2.5-kb first intron, and 15 bp of exon 2, driving expression of human aldo-keto reductase family 1, member B (also called aldose reductase). Transgenic mice express AKR1B1 specifically in both vascular and nonvascular smooth muscle cells and also in the cone bipolar cells of the retina. (J:43053, J:195671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:195671 Kador PF, et al., Novel diabetic mouse models as tools for investigating diabetic retinopathy. PLoS One. 2012;7(12):e49422
• All: 3 reference(s)