Cftr^tm2.1Cwr
Targeted Allele Detail

Summary

• Symbol: Cftr^tm2.1Cwr
• Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 2.1, Case Western Reserve University
• MGI ID: MGI:5804672
• Synonyms: Cftr^invfl10, Cftr^invfl10Exon 11 inverted
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^tm2.1Cwr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 11 (exon 10 in legacy exon numbering) was replaced with a floxed, inverted exon 11. The final allele lacks a selection cassette. (J:234604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 97 strains or lines available

References

• Original: J:234604 Hodges CA, et al., Cystic fibrosis growth retardation is not correlated with loss of Cftr in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2011 Sep;301(3):G528-36
• All: 2 reference(s)