Hmga2^tm1.2Mmw
Targeted Allele Detail

Summary

• Symbol: Hmga2^tm1.2Mmw
• Name: high mobility group AT-hook 2; targeted mutation 1.2, Monte Winslow
• MGI ID: MGI:5804457
• Synonyms: Hmga2^GFP
• Gene: Hmga2 Location: Chr10:120197180-120312374 bp, - strand Genetic Position: Chr10, 67.94 cM
• Alliance: Hmga2^tm1.2Mmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211779
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with 3' loxP2272 and loxP5171 site was inserted upstream of exon 2. An inverted EGFP expression cassette with 3' loxP2272 and loxP5171 sites was inserted downstream of exon 2 without affecting Mir763. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination reversed the reporter cassette and exon 2. (J:211779)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmga2 Mutation: 12 strains or lines available

References

• Original: J:211779 Chiou SH, et al., A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Cell Rep. 2014 Jun 26;7(6):2078-86
• All: 1 reference(s)