Aurkb^tm3.1Mama
Targeted Allele Detail

Summary

• Symbol: Aurkb^tm3.1Mama
• Name: aurora kinase B; targeted mutation 3.1, Marcos Malumbres
• MGI ID: MGI:5804101
• Synonyms: Aurkb^tet
• Gene: Aurkb Location: Chr11:68936477-68942490 bp, + strand Genetic Position: Chr11, 42.32 cM
• Alliance: Aurkb^tm3.1Mama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228221
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The minimal tetracycline-cytomegalovirus promoter (Tet-P) was inserted upstream of exon 1. Cre-mediated recombination removed the floxed puromycin resistance cassette inserted upstream of the inserted promoter. (J:228221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aurkb Mutation: 25 strains or lines available

References

• Original: J:228221 Gonzalez-Loyola A, et al., Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Mol Cell Biol. 2015 Oct;35(20):3566-78
• All: 1 reference(s)