Tg(Ins2-GLUD1*H454Y)2Csta
Transgene Detail

Summary

• Symbol: Tg(Ins2-GLUD1*H454Y)2Csta
• Name: transgene insertion 2, Charles A Stanley
• MGI ID: MGI:5796776
• Synonyms: TG-2
• Transgene: Tg(Ins2-GLUD1*H454Y)2Csta Location: unknown
• Alliance: Tg(Ins2-GLUD1*H454Y)2Csta page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-GLUD1*H454Y)2Csta expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GLUD1 (2746)

  Glud1

  (MGI:95753)

• Tg(Ins2-GLUD1*H454Y)2Csta expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat insulin promoter drives beta-cell specific expression of the human glutamate dehydrogenase 1 with the H454Y mutation. Two lines, TG-1 and TG-2 were established. This is the higher expressing line. (J:113458)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:113458 Li C, et al., Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice. J Biol Chem. 2006 Jun 2;281(22):15064-72
• All: 1 reference(s)