Sumf1^tm1Clear
Targeted Allele Detail

Summary

• Symbol: Sumf1^tm1Clear
• Name: sulfatase modifying factor 1; targeted mutation 1, Andrea Ballabio
• MGI ID: MGI:5796637
• Gene: Sumf1 Location: Chr6:108083989-108162543 bp, - strand Genetic Position: Chr6, 49.71 cM
• Alliance: Sumf1^tm1Clear page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188481
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site4 was introduced upstream and a frt site-flanked neomycin resistance cassette followed by a second loxP site downstream of exon 4. Cre recombinase excision of the floxed DNA segment would result in a reading frame shift leading to a premature termination codon. (J:188481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sumf1 Mutation: 33 strains or lines available

References

• Original: J:188481 Di Malta C, et al., Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2334-42
• All: 1 reference(s)