Commd9^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Commd9^{tm1c(KOMP)Wtsi}
• Name: COMM domain containing 9; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5796331
• Synonyms: Commd9^F
• Gene: Commd9 Location: Chr2:101716607-101731984 bp, + strand Genetic Position: Chr2, 54.07 cM
• Alliance: Commd9^{tm1c(KOMP)Wtsi} page
• IMPC: Commd9 gene page

Mutation origin

• Mutant Cell Line: EPD0136_6_D10
• Germline Transmission: Earliest citation of germline transmission: J:230747
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Vector: L1L2_Bact_P Mutation details: The L1L2_Bact_P cassette was inserted at position 101726764 of Chromosome 2 upstream of exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 101727794. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, resulting in the deletion of the lacZ sequences and the neomycin selection cassette. Exon 3 is thus flanked by loxP sites. (J:230747)

Generation of the Commd9^tm1c(KOMP)Wtsi allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Commd9 Mutation: 49 strains or lines available

References

• Original: J:230747 Li H, et al., Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J Cell Biol. 2015 Nov 9;211(3):605-17
• All: 5 reference(s)