Itpr2^tm1.1Amks
Targeted Allele Detail

Summary

• Symbol: Itpr2^tm1.1Amks
• Name: inositol 1,4,5-triphosphate receptor 2; targeted mutation 1.1, Andrew R Marks
• MGI ID: MGI:5796179
• Synonyms: IP3R2^fl, IP3R2^flox
• Gene: Itpr2 Location: Chr6:146009797-146403721 bp, - strand Genetic Position: Chr6, 77.7 cM
• Alliance: Itpr2^tm1.1Amks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226507
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 is floxed. No selection cassette remains in the final allele. (J:226507)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpr2 Mutation: 150 strains or lines available

References

• Original: J:226507 Santulli G, et al., Mitochondrial calcium overload is a key determinant in heart failure. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11389-94
• All: 2 reference(s)