Ryr2^tm5.1Amks
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm5.1Amks
• Name: ryanodine receptor 2, cardiac; targeted mutation 5.1, Andrew R Marks
• MGI ID: MGI:5796177
• Synonyms: RyR2-S2808D
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm5.1Amks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171862
• Parent Cell Line: MM13 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 55 was replaced wiht one in which nucleotide substitution(s) result(s) in the amino acid substitution of aspartic acid for serine at position 2808 (S2808D). A self-excising neomycin resistance cassette is removed from the final allele. (J:171862)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 330 strains or lines available

References

• Original: J:171862 Shan J, et al., Role of chronic ryanodine receptor phosphorylation in heart failure and beta-adrenergic receptor blockade in mice. J Clin Invest. 2010 Dec 1;120(12):4375-87
• All: 3 reference(s)