Gt(ROSA)26Sor^{tm2(CAG-Kdm1a)Rsd}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-Kdm1a)Rsd}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Michael G Rosenfeld
• MGI ID: MGI:5796142
• Synonyms: FLAG-Lsd1n
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-Kdm1a)Rsd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225803
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(CAG-Kdm1a)Rsd} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kdm1a (MGI:1196256)	neuronal isoform

• Mutation details: The targeting vector inserted into the locus a CAG promoter, floxed stop cassette and a FLAG-tagged sequence for the neuronal form containing exon 8a with or without exon 2a. (J:225803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:225803 Wang J, et al., LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nat Neurosci. 2015 Sep;18(9):1256-64
• All: 1 reference(s)