Ubl4a^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Ubl4a^tm1.2Arte
• Name: ubiquitin-like 4A; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:5795865
• Gene: Ubl4a Location: ChrX:73409324-73412154 bp, - strand Genetic Position: ChrX, 38.0 cM
• Alliance: Ubl4a^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226059
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 4. Western blot analysis confirmed the absence of protein expression in the liver. (J:226059)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubl4a Mutation: 4 strains or lines available

References

• Original: J:226059 Zhao Y, et al., Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9644-9
• All: 4 reference(s)