Chmp5^tm2.1Gho
Targeted Allele Detail

Summary

• Symbol: Chmp5^tm2.1Gho
• Name: charged multivesicular body protein 5; targeted mutation 2.1, Sankor Ghosh
• MGI ID: MGI:5795733
• Synonyms: Chmp5^fl
• Gene: Chmp5 Location: Chr4:40948553-40965302 bp, + strand Genetic Position: Chr4, 20.69 cM
• Alliance: Chmp5^tm2.1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226432
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4 and 5 were floxed. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:226432)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chmp5 Mutation: 16 strains or lines available

References

• Original: J:226432 Greenblatt MB, et al., CHMP5 controls bone turnover rates by dampening NF-kappaB activity in osteoclasts. J Exp Med. 2015 Jul 27;212(8):1283-301
• All: 2 reference(s)