Tln1^tm2.1Bpet
Targeted Allele Detail

Summary

• Symbol: Tln1^tm2.1Bpet
• Name: talin 1; targeted mutation 2.1, Brian G Petrich
• MGI ID: MGI:5793036
• Synonyms: Tln1^W359A
• Gene: Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
• Alliance: Tln1^tm2.1Bpet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (TGG to GCG) resulted in the amino acid substitution of alanine for tryptophan at position 359 (W359A). Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:210743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tln1 Mutation: 145 strains or lines available

References

• Original: J:210743 Stefanini L, et al., A talin mutant that impairs talin-integrin binding in platelets decelerates alphaIIbbeta3 activation without pathological bleeding. Blood. 2014 Apr 24;123(17):2722-31
• All: 3 reference(s)