Txn2^tm1Wami
Targeted Allele Detail

Summary

• Symbol: Txn2^tm1Wami
• Name: thioredoxin 2; targeted mutation 1, Wang Min
• MGI ID: MGI:5792730
• Synonyms: Trx2^lox
• Gene: Txn2 Location: Chr15:77799251-77813194 bp, - strand Genetic Position: Chr15, 36.92 cM
• Alliance: Txn2^tm1Wami page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234135
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• A neomycin resistance cassette with a 3' loxP site was inserted downstream of the floxed exon 3. (J:234135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txn2 Mutation: 26 strains or lines available

References

• Original: J:234135 Huang Q, et al., Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function. Circulation. 2015 Mar 24;131(12):1082-97
• All: 5 reference(s)