Kdm6b^tm1.1Cdcn
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1.1Cdcn
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.1, Charlie Degui Chen
• MGI ID: MGI:5792729
• Synonyms: Jmjd3^-
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1.1Cdcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233350
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT site flanked neomycin resistance cassette with a 5' loxP site was inserted into intron 13. An additional loxP site was inserted into intron 20. Cre-mediated recombination removed the selection cassette and exons 14 through 20. Western blot analysis confirmed the absence of protein in E14.5 limbs. (J:233350)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 65 strains or lines available

References

• Original: J:233350 Zhang F, et al., JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol. 2015 Feb;7(1):23-34
• All: 1 reference(s)