Dll1^{tm7.1(Dll1)Gos}
Targeted Allele Detail

Summary

• Symbol: Dll1^{tm7.1(Dll1)Gos}
• Name: delta like canonical Notch ligand 1; targeted mutation 7.1, Achim Gossler
• MGI ID: MGI:5790945
• Synonyms: Dll1^Dll1ki
• Gene: Dll1 Location: Chr17:15587616-15597134 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Dll1^{tm7.1(Dll1)Gos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234164
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, No functional change, Null/knockout)
• Mutations: Duplication, Insertion
• Mutation details: A minigene containing the coding sequence of the inserted gene was coupled to genomic sequence containing the last three exons (3' part of exon 9 through entire exon 11) of the host gene. This combined sequence followed by a loxP-flanked neomycin resistance gene cassette was inserted at the ATG translation start site of the host gene. Subsequent cre-mediated recombination removed the neo cassette. Experiments confirm the functional expression of the inserted gene. This allele was generated as an experimental control, the inserted gene being the same as the host gene. (J:234164)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dll1 Mutation: 46 strains or lines available

References

• Original: J:234164 Geffers I, et al., Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol. 2007 Jul 30;178(3):465-76
• All: 2 reference(s)