Gprc6a^tm1.1Pwd
Targeted Allele Detail

Summary

• Symbol: Gprc6a^tm1.1Pwd
• Name: G protein-coupled receptor, family C, group 6, member A; targeted mutation 1.1, Petrine Wellendorph
• MGI ID: MGI:5790352
• Gene: Gprc6a Location: Chr10:51490919-51507554 bp, - strand Genetic Position: Chr10, 25.66 cM
• Alliance: Gprc6a^tm1.1Pwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233141
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 5 and an FRT site flanked neomycin resistance cassette plus a second loxP site were inserted in intron 6. Subsequent cre-expression removed the floxed exon 6 (and the neo cassette). (J:233141)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprc6a Mutation: 65 strains or lines available

References

• Original: J:233141 Wellendorph P, et al., No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. J Mol Endocrinol. 2009 Mar;42(3):215-23
• All: 3 reference(s)