Snap91^tm1.1Tmar
Targeted Allele Detail

Summary

• Symbol: Snap91^tm1.1Tmar
• Name: synaptosomal-associated protein 91; targeted mutation 1.1, Tanja Maritzen
• MGI ID: MGI:5788722
• Synonyms: AP180^-
• Gene: Snap91 Location: Chr9:86647976-86762707 bp, - strand Genetic Position: Chr9, 46.58 cM, cytoband E3.2
• Alliance: Snap91^tm1.1Tmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228428
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted in front of exon 3 and an additional loxP site after exon 6. Mice were mated with Ella-Cre Deleter mice to remove the neomycin resistance cassette as well as exons 3 to 6, leaving behind a single loxP site between exon 2 and 7. Western blot analysis confirmed absence of protein expression in brain lysates from adult homozygous mutant mice. (J:228428)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snap91 Mutation: 51 strains or lines available

References

• Original: J:228428 Koo SJ, et al., Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission. Neuron. 2015 Oct 21;88(2):330-44
• All: 5 reference(s)