Hacd1^tm1.1Pas
Targeted Allele Detail

Summary

• Symbol: Hacd1^tm1.1Pas
• Name: 3-hydroxyacyl-CoA dehydratase 1; targeted mutation 1.1, Institut Pasteur
• MGI ID: MGI:5788548
• Gene: Hacd1 Location: Chr2:14031642-14060846 bp, - strand Genetic Position: Chr2, 10.3 cM, cytoband A2
• Alliance: Hacd1^tm1.1Pas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The KOMP targeting vector (PRPGS00067_A_B09) introduced an FRTt site, beta-galactosidase cassette, loxP site, neomhycin resistance cassette, FRT site, and loxP site upstream of exon 2 in addition to inserting a loxP site downstream of exon 4. Cre-mediated recombination removed the selection cassette and exons 2 through 4. The beta-galactosidase reporter gene remains intact. (J:226931)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hacd1 Mutation: 16 strains or lines available

References

• Original: J:226931 Blondelle J, et al., HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. J Mol Cell Biol. 2015 Oct;7(5):429-40
• All: 2 reference(s)